The French have a phrase for this (of course they do, who better to describe malaise?): ne pas ĂȘtre bien dans sa peau. I first encountered it in my HS French class reading Camus or a North African author whom I have forgotten in a ridiculous bout of shallow callowness.
"Je ne suis pas bien dans ma peau."
I can just hear her saying that. "My skin hurts." I think Joplin had the same pain, and Hendrix. Morrison as well. And Cobain. All dead at 27. Such a fucking waste.
Rest in peace little girl. I am choosing to imagine you and Pearl with your arms thrown around each other, open-throated and comfortable in your skin.